When infected with a virus that blocks most programs from running it can be hard to kill off the task. You can not delete a file while it is in use. We normally recommend users simply re-name the file and then re-boot the computer.
A better but slighlty more complicated way is to use the command line to terminate/kill the task and then delete the file.
This video covers how to do that.
The above video was for a file located at
c:\Users\Jacob\AppData\Roaming\
The command we used was
taskkill /f /im Protector-Irtp.exe
You can do the exact same by first browsing in the command line to the directory where the file is located. Then type in the above commande of "taskkill /f /im processname.exe" of course processname.exe is the name of the process you are wanting to kill.
Once this is done you can easily delete the file with out having to re-boot your computer after renaming it.
Another in-depth article covering more technical information about taskkill can be found at http://technet.microsoft.com/en-us/library/bb491009.aspx
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